effect of wr-1065 on 6-hydroxydopamine-induced catalepsy and il-6 level in rats
نویسندگان
چکیده
objective(s): neuroinflammation and oxidative stress play a key role in pathogenesis of parkinson’s disease (pd). in the present study we investigated the effect of reactive oxygen species (ros) scavenger wr-1065 on catalepsy and cerebrospinal fluid (csf) level of interleukin 6(il-6) and striatum superoxide dismutase (sod) activity in 6-hydroxydopamine (6-ohda) induced experimental model of pd. materials and methods: seventy two male wistar rats were divided into 9 equal groups and 6-ohda (8 μg/2 μl/rat) was infused unilaterally into substantia nigra pars copmacta (snc) to induce pd. catalepsy was measured by standard bar test, csf level of il-6 was assessed by enzyme-linked immunosorbent assay (elisa) method and sod activity measured by spectrophotometric method. in pre-treatment groups wr-1065 (20, 40 and 80 μg/2 μl/rat/day, for 3 days) was infused into the snc before 6-ohda administration and 21 days later, as a recovery period, behavioral and molecular assay tests were done. results: our results showed that pre-treatment with wr-1065 improved (p<0.001) 6-ohda-induced catalepsy in a dose dependent manner. in 6-ohda-lesioned animals sod activity in snc and csf level of il-6 was decreased markedly (p<0.001) when compared with non-lesioned group, while pre-treatment with wr-1065(p<0.001) restored their levels up to the normal range. conclusion: our study indicated that pre-treatment with wr-1065 could modulate catalepsy and il-6 level in 6-ohda-lesioned rats. also wr1065 could increase sod activity up to normal range. it can be regarded as an anti-oxidative drug in prevention or adjunctive therapy of pd.
منابع مشابه
Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats
Objective(s): Neuroinflammation and oxidative stress play a key role in pathogenesis of Parkinson’s disease (PD). In the present study we investigated the effect of reactive oxygen species (ROS) scavenger WR-1065 on catalepsy and cerebrospinal fluid (CSF) level of interleukin 6(IL-6) and striatum superoxide dismutase (SOD) activity in 6-hydroxydopamine (6-OHDA) induced experimental model of PD...
متن کاملEffect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats
OBJECTIVES Neuroinflammation and oxidative stress play a key role in pathogenesis of Parkinson's disease (PD). In the present study we investigated the effect of reactive oxygen species (ROS) scavenger WR-1065 on catalepsy and cerebrospinal fluid (CSF) level of interleukin 6(IL-6) and striatum superoxide dismutase (SOD) activity in 6-hydroxydopamine (6-OHDA) induced experimental model of PD. ...
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Receptors for 5-HT(1A) are widely distributed throughout the basal ganglia, and their activation results in an inhibition of dopamine (DA) release. This study aimed to investigate the effect of buspirone, as a partial agonist of 5-HT(1A) receptors, on 6-hydroxydopamine (6-OHDA)-induced catalepsy in male Wistar rats. Catalepsy was induced by unilateral infusion of 6-OH-DA (6 microg/2 microl/rat)...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۹، شماره ۵، صفحات ۴۹۰-۴۹۶
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